Tracheal cytotoxin
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Tracheal Cytotoxin. That molecule is tracheal cytotoxin TCT which is released by B. Avium is a 155000-molecular-weight heat-labile protein which was lethal for mice guinea pigs young chickens and turkey poults and produced dermonecrosis when injected intradermally into guinea pigs chickens and turkey poults. Tracheal cytotoxin TCT is alow molecular weight glyco-peptide released during logarithmic-phase growthofBorde-tella pertussis. We have previously determined the structure of TCT to be GlcNAc-16-anhydro-MurNAc-L-Ala-gamma-D-Glu-meso-A2pm-D-Ala where MurNAc N-acetylmuramic acid and A2pm diaminopimelic acid.
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It induces the heterodimerization of its recognition receptors the peptidoglycan recognition proteins PGRPs LCa and LCx which activates the immune deficiency pathway. Tracheal cytotoxin TCT is the only virulence factor produced by B. Doglycan fragment of its cell wall called tracheal cytotoxin TCTwhichdamagesbothhuman28 andanimal 6 13 15 airway epithelium in vitro. Unlike most other Bordetella toxins tracheal cytotoxin is expressed constitutively being a normal product of the breakdown of the bacterial cell wall. TCT is the major peptidoglycan fragmentreleasedbythe bacterium andits structure hasbeen fully characterized and shown to consist of a disaccharide tetrapeptide containing glucosamine muramic acid. Pertussis toxin tracheal cytotoxin TCT which reproduces in vitro the specific ciliated cell damage seen in humans.
Unlike most other Bordetella toxins tracheal cytotoxin is expressed constitutively being a normal product of the breakdown of the bacterial cell wall.
Unlike most other Bordetella toxins tracheal cytotoxin is expressed constitutively being a normal product of the breakdown of the bacterial cell wall. The dermonecrotic toxin of B. Tracheal cytotoxin TCT is alow molecular weight glyco-peptide released during logarithmic-phase growthofBorde-tella pertussis. Tracheal cytotoxin TCT is released during log phase broth culture and consists of 15 amino acid residues as well as two amino sugars. Avium is a 155000-molecular-weight heat-labile protein which was lethal for mice guinea pigs young chickens and turkey poults and produced dermonecrosis when injected intradermally into guinea pigs chickens and turkey poults. Tracheal cytotoxin TCT is the only virulence factor produced by B.
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TCT is the major peptidoglycan fragmentreleasedbythe bacterium andits structure hasbeen fully characterized and shown to consist of a disaccharide tetrapeptide containing glucosamine muramic acid. The methods and compositions of the invention are useful for the treatment of Th2-mediated diseases and conditions due to their utility in suppressing Th2-mediated. The present invention provides compositions and methods for the suppression of Th2-mediated immune response. Avium produced a dermonecrotic toxin and a tracheal cytotoxin. Tracheal cytotoxin is abbreviated as TCT.
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Doglycan fragment of its cell wall called tracheal cytotoxin TCTwhichdamagesbothhuman28 andanimal 6 13 15 airway epithelium in vitro. Tracheal cytotoxin TCT is a disaccharide-tetrapeptide released by Bordetella pertussis the causative agent of pertussis whooping cough. In 1982 we reported the identification of a B. Tracheal cytotoxin TCT is the only virulence factor produced by B. It induces the heterodimerization of its.
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