Organotin toxicity
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Organotin Toxicity. Most of the toxic effects of organotin complexes are irreversible dose- and time dependent and can be divided into Ca 2 -independent and Ca 2 -dependent mechanisms but they are strictly linked. Environmental organotins are also neurotoxic. In rodents organotin exposure induces developmental and reproductive toxicity as well as alteration of metabolic homeostasis through its action as an obesogen. They are harmful not only for humans but also for other animals and plants.
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Avio et al 2017. Verschoyle RD Little RA. Their principal use is in clear vinyl products. The family includes potent neurotoxicants and immunotoxicants and some OTs have characteristics of reproductive and developmental toxicants. In vitro tests designed to explore organotin action modes at cell level by minimizing interfering factors point out akin responses to these man-made environmental pollutants from prokaryotes to mammals. Over the years a variety of uses has been found for organic and inorganic tin compounds as fungicides as stablizers in plastics moluscicides and miticides.
They produce endocrine-disrupting effects in mollusks such as imposex.
Food and Drug Administration Washington DC. Combined toxicity of organotin compounds and other pollutants EP include pollutants that produce excessive chemicals andor biological substances used in households industry and manufacturing Ahmed et al 2017. Avio et al 2017. Focus on Kidney Organotin compounds OTs are synthetic persistent organometallic xenobiotics widely used in several commercial applications. Toxicity of organotin compounds for polymorphonuclear leukocytes. Organotin Toxicity PVC FACTS HOMEPAGE CONTACT US.
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Organotin Toxicity PVC FACTS HOMEPAGE CONTACT US. In vitro tests designed to explore organotin action modes at cell level by minimizing interfering factors point out akin responses to these man-made environmental pollutants from prokaryotes to mammals. Focus on Kidney Organotin compounds OTs are synthetic persistent organometallic xenobiotics widely used in several commercial applications. They have also been suggested as insect chemosterilants and for other industrial uses. In rodents organotin exposure induces developmental and reproductive toxicity as well as alteration of metabolic homeostasis through its action as an obesogen.
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They produce endocrine-disrupting effects in mollusks such as imposex. Combined toxicity of organotin compounds and other pollutants EP include pollutants that produce excessive chemicals andor biological substances used in households industry and manufacturing Ahmed et al 2017. They induce behavioral abnormality and are toxic to the developing central nervous system. Organotins principally dibutyltin and monobutyltin are used as stabilizers in Vinyl as an alternative to Lead and Cadmium. New article July 2000.
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Over the years a variety of uses has been found for organic and inorganic tin compounds as fungicides as stablizers in plastics moluscicides and miticides. They are harmful not only for humans but also for other animals and plants. Here the aquatic ecotoxicology of organotins is reviewed based on a multidisciplinary approach involving environmental chemical toxicological and ecological aspects. The family includes potent neurotoxicants and immunotoxicants and some OTs have characteristics of reproductive and developmental toxicants. Organotins OTs are a family of chemicals that vary widely in their toxicity.
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The effect on phagocytosis and exocytosis. From an environmental toxicological perspective the two most widely studied OTs are tributyltin TBT1 and triphenyltin TPhT. There is a consequence of using the organotin as antifoulants that is their exceptional toxicity to marine organisms non-target. Organotins OTs are a family of chemicals that vary widely in their toxicity. Verschoyle RD Little RA.
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They are harmful not only for humans but also for other animals and plants. Organotin Toxicity PVC FACTS HOMEPAGE CONTACT US. Organotin compounds found to interfere with immune system cell activity. They have mutagenic as well as carcinogenic effects. There is a consequence of using the organotin as antifoulants that is their exceptional toxicity to marine organisms non-target.
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They induce behavioral abnormality and are toxic to the developing central nervous system. A comprehensive review on toxicity of organotin compounds including sources of their intake and mode of action and cardiovascular activity of organotin compounds is presented. They produce endocrine-disrupting effects in mollusks such as imposex. They have also been suggested as insect chemosterilants and for other industrial uses. Food and Drug Administration Washington DC.
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Most of the toxic effects of organotin complexes are irreversible dose- and time dependent and can be divided into Ca 2 -independent and Ca 2 -dependent mechanisms but they are strictly linked. Organotin compounds exert a number of cellular biochemical and molecular effects and toxicity is primarily influenced by bioavailability of the toxicant route of exposure and the level and time course of exposure. Their principal use is in clear vinyl products. Over the years a variety of uses has been found for organic and inorganic tin compounds as fungicides as stablizers in plastics moluscicides and miticides. Toxicity of organotin compounds for polymorphonuclear leukocytes.
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In vitro studies have shown that organotins induce intracellular Ca2 elevation and glutamate excitotoxicity. In vitro tests designed to explore organotin action modes at cell level by minimizing interfering factors point out akin responses to these man-made environmental pollutants from prokaryotes to mammals. The effect on phagocytosis and exocytosis. They are harmful not only for humans but also for other animals and plants. Organotin compounds exert a number of cellular biochemical and molecular effects and toxicity is primarily influenced by bioavailability of the toxicant route of exposure and the level and time course of exposure.
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Both di- and trialkyltin compounds are potent inhibitors of. They exert well-described harmful effects in brain liver adipose tissue and reproductive organs as they are endocrine-disrupting chemicals EDCs but the effects in the. Organotin compounds exert a number of cellular biochemical and molecular effects and toxicity is primarily influenced by bioavailability of the toxicant route of exposure and the level and time course of exposure. They are harmful not only for humans but also for other animals and plants. Elferink JG Deierkauf M Van Steveninck J.
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The family includes potent neurotoxicants and immunotoxicants and some OTs have characteristics of reproductive and developmental toxicants. Over the years a variety of uses has been found for organic and inorganic tin compounds as fungicides as stablizers in plastics moluscicides and miticides. However such organotin compounds are very toxic. In vitro studies have shown that organotins induce intracellular Ca2 elevation and glutamate excitotoxicity. Organotin compounds exert a number of cellular biochemical and molecular effects and toxicity is primarily influenced by bioavailability of the toxicant route of exposure and the level and time course of exposure.
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1Division of Toxicological Review and Evaluation US. Here the aquatic ecotoxicology of organotins is reviewed based on a multidisciplinary approach involving environmental chemical toxicological and ecological aspects. Basic results were obtained both with field and laboratory studies and some of the most important recent results and conclusions are critically reviewed. Their principal use is in clear vinyl products. In vitro tests designed to explore organotin action modes at cell level by minimizing interfering factors point out akin responses to these man-made environmental pollutants from prokaryotes to mammals.
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Most biochemical effects of organotin compounds leading to toxicity are astonishingly similar in different animal species. They have also been suggested as insect chemosterilants and for other industrial uses. They have mutagenic as well as carcinogenic effects. Organotin compounds found to interfere with immune system cell activity. In vitro tests designed to explore organotin action modes at cell level by minimizing interfering factors point out akin responses to these man-made environmental pollutants from prokaryotes to mammals.
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The general pattern of toxicity is trisubstituted organotins disubstituted organotins monosubstituted organotins tetrasubstituted organotins. Over the years a variety of uses has been found for organic and inorganic tin compounds as fungicides as stablizers in plastics moluscicides and miticides. There is a consequence of using the organotin as antifoulants that is their exceptional toxicity to marine organisms non-target. Focus on Kidney Organotin compounds OTs are synthetic persistent organometallic xenobiotics widely used in several commercial applications. The acute toxicity of triphenyl tributyl and dibutyllead in the rat appears to result from their irritating properties to membranes regardless of.
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Environmental organotins are also neurotoxic. In rodents organotin exposure induces developmental and reproductive toxicity as well as alteration of metabolic homeostasis through its action as an obesogen. Phagocytosis and concomitant release of enzymes by rabbit polymorphonuclear leukocytes PMNs are inhibited by micromolar concentrations of triphenyltin and tributyltin. Food and Drug Administration Washington DC. From an environmental toxicological perspective the two most widely studied OTs are tributyltin TBT1 and triphenyltin TPhT.
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They produce endocrine-disrupting effects in mollusks such as imposex. Elferink JG Deierkauf M Van Steveninck J. Food and Drug Administration Washington DC. They have also been suggested as insect chemosterilants and for other industrial uses. The acute toxicity of triphenyl tributyl and dibutyllead in the rat appears to result from their irritating properties to membranes regardless of.
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