Hexosamine biosynthetic pathway
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Hexosamine Biosynthetic Pathway. The hexosamine biosynthetic pathway HBP which is linked to metabolism of glucose FAs and amino acids has been implicated in various models of heart disease. CAS Article Google Scholar 24. Glycolysis is a process that rapidly converts glucose to lactate to produce adenosine triphosphate ATP under anaerobic conditions and occurs in all eukaryotic and prokaryotic cells. Weigert C Brodbeck K Sawadogo M Haring HU Schleicher ED.
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Recently it was demonstrated that HBP influences many aspects of tumor biology. Glucose enters the cell and undergoes two-step conversion to fructose-6P fructose-6-phosphate after which approximately 95 of it proceeds to glycolysis and 35 of it is converted to glucosamine-6P glucosamine-6-phosphate by the enzyme GFAT glutaminefructose-6-phosphate amidotransferase utilizing glutamine that enters the cell. Weigert C Brodbeck K Sawadogo M Haring HU Schleicher ED. By employing various models of HF including aortic constriction. The hexosamine biosynthetic pathway. Glucose glutamine fatty acids and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway HBP.
Recently it was demonstrated that HBP influences many aspects of tumor biology.
Weigert C Brodbeck K Sawadogo M Haring HU Schleicher ED. The hexosamine biosynthetic pathway has been hypothesized to be involved in the development of insulin resistance and diabetic vascular complications. The role of the hexosamine biosynthetic pathway in diabetic nephropathy. Recently the role of the HBP in HF has also received special interest. The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. The hexosamine biosynthetic pathway HBP plays critical roles in nutrient sensing stress response and cell growth.
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The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. By employing various models of HF including aortic constriction. Weigert C Brodbeck K Sawadogo M Haring HU Schleicher ED. Cancer cells present altered glucose metabolism and aberrant glycosylation pointing to alterations on HBP. The hexosamine biosynthetic pathway.
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