Cd138
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Cd138. The criteria for CD138 immunohistochemically stained specimens 9 12. A 69-year-old man with a history of CD138 plasma cell myeloma PCM who received chemotherapy regimens and stem cell transplant presented for bone marrow biopsy which revealed sheets of atypical plasma cells with abundant amphophilic cytoplasm occasional binucleation and distinct perinuclear hof panels A-B. The protein is useful to diagnose any neoplasms tumors growing in plasma cells. Within the hemopoietic system CD138 is mainly confined to late stages of B-cell differentiation.
Histopathology Images Of Plasma Cell Leukemia Primary By Pathpedia Com Pathology E Atlas Hematology Leukemia Plasma From id.pinterest.com
CD138 protein and mRNA levels were first assayed by flow cytometry analysis using an anti-CD138 DL-101 clone and qRT-PCR respectively in MM cell lines n. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. CD138 syndecan-1 is a transmembrane proteoglycan with a main cellular expression in stratified and simple epithelia. CD138 also designated syndecan-1 is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. After CD138 immunohistochemistry staining the plasma cell membrane showed strong positive staining while the cytoplasm showed weak positive stainingUnder microscopic observation the nucleus was rounded but located on one side of the cell and the thick chromatin was radially arranged along the nuclear.
The CD138 molecule is a transmembrane heparan sulphate glycoprotein expressed at distinct stages of differentiation in normal lymphoid cells such as pre-B cells immature B cells and Ig-producing plasma cells as well as being expressed in stratified and simple epithelia.
It is further found on a subset of plasma cells in peripheral blood and certain lymphoid tissues. The CD138 molecule is a transmembrane heparan sulphate glycoprotein expressed at distinct stages of differentiation in normal lymphoid cells such as pre-B cells immature B cells and Ig-producing plasma cells as well as being expressed in stratified and simple epithelia. If a patient is to be tested for cancer CD138 stains can be used to spot tumor cells. Within the hemopoietic system CD138 is mainly confined to late stages of B-cell differentiation. CD138 syndecan-1 a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Epithelial cells and endothelial cells may also express CD138.
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We evaluated the immunohistochemical profile and specificity of CD138 reactivity in 238 specimens from hematopoietic and nonhematopoietic neoplasms. After CD138 immunohistochemistry staining the plasma cell membrane showed strong positive staining while the cytoplasm showed weak positive stainingUnder microscopic observation the nucleus was rounded but located on one side of the cell and the thick chromatin was radially arranged along the nuclear. It is further found on a subset of plasma cells in peripheral blood and certain lymphoid tissues. CD138 Syndecan-1 is a heparan sulfate-rich integral membrane proteoglycan which functions as a matrix receptor for interstitial collagens fibronectin and thrombospondin. The criteria for CD138 immunohistochemically stained specimens 9 12.
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CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. The CD138 antigen is neither expressed on naive B cells germinal center B cells memory B cells nor on T cells or monocytes. CD138 is a protein present on plasma cells in the bone marrow and on certain epithelial cells. Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma SCC of head and neck and larynx. CD138 is predominantly expressed on the surface of epithelial cells in mature mouse tissues.
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CD138 is predominantly expressed on the surface of epithelial cells in mature mouse tissues. If a patient is to be tested for cancer CD138 stains can be used to spot tumor cells. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. The loss of CD138 expression from atypical cells is reported to be an early. Original magnification 100 Wright-Giemsa stain A and 40.
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Levels also reduced in invasive SCC but not in SCC in situ Interpretation. Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma SCC of head and neck and larynx. If a patient is to be tested for cancer CD138 stains can be used to spot tumor cells. CD138 expression is reduced during malignant transformation of various epithelia and CD138 is. The CD138 antigen is neither expressed on naive B cells germinal center B cells memory B cells nor on T cells or monocytes.
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Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma SCC of head and neck and larynx. The loss of CD138 expression from atypical cells is reported to be an early. Epithelial cells and endothelial cells may also express CD138. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms.
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Using this method plasma cells are selected from the population of CD38 cells by exclusion of all nonplasma cells with CD38 positivity using lineage specific markers such as CD3 CD14 CD16 CD19 and CD123. After CD138 immunohistochemistry staining the plasma cell membrane showed strong positive staining while the cytoplasm showed weak positive stainingUnder microscopic observation the nucleus was rounded but located on one side of the cell and the thick chromatin was radially arranged along the nuclear. Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma SCC of head and neck and larynx. CD138syndecan-1 B-A38 Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the CD138syndecan-1 protein in formalin-fixed paraffin-embedded tissue stained on VENTANA BenchMark IHCISH instruments. Using this method plasma cells are selected from the population of CD38 cells by exclusion of all nonplasma cells with CD38 positivity using lineage specific markers such as CD3 CD14 CD16 CD19 and CD123.
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We evaluated the immunohistochemical profile and specificity of CD138 reactivity in 238 specimens from hematopoietic and nonhematopoietic neoplasms. CD138syndecan-1 B-A38 Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the CD138syndecan-1 protein in formalin-fixed paraffin-embedded tissue stained on VENTANA BenchMark IHCISH instruments. In addition because of its clear-cut cell membrane localization CD138 can be used successfully in double-marker immunostaining reactions to evaluate precisely nuclear prognostic markers such as Ki67 and p53 in. CD138 Concentrate Clone MI15. Epithelial cells and endothelial cells may also express CD138.
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A 69-year-old man with a history of CD138 plasma cell myeloma PCM who received chemotherapy regimens and stem cell transplant presented for bone marrow biopsy which revealed sheets of atypical plasma cells with abundant amphophilic cytoplasm occasional binucleation and distinct perinuclear hof panels A-B. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. CD138 is predominantly expressed on the surface of epithelial cells in mature mouse tissues. The CD138 antigen is neither expressed on naive B cells germinal center B cells memory B cells nor on T cells or monocytes. The canonical plasma cell marker CD138 syndecan-1 is highly expressed on the myeloma cell surface but its functional role in vivo is unclear as well as the ontogeny of CD138-high and CD138.
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The CD138 antigen is neither expressed on naive B cells germinal center B cells memory B cells nor on T cells or monocytes. CD138 Concentrate Clone MI15. CD138 syndecan-1 a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. The criteria for CD138 immunohistochemically stained specimens 9 12. Using this method plasma cells are selected from the population of CD38 cells by exclusion of all nonplasma cells with CD38 positivity using lineage specific markers such as CD3 CD14 CD16 CD19 and CD123.
Source: pinterest.com
CD138 expression is reduced during malignant transformation of various epithelia and CD138 is. CD138 syndecan-1 a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. CD138 also designated syndecan-1 is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. CD138 protein and mRNA levels were first assayed by flow cytometry analysis using an anti-CD138 DL-101 clone and qRT-PCR respectively in MM cell lines n. The protein is useful to diagnose any neoplasms tumors growing in plasma cells.
Source: pinterest.com
Epithelial cells and endothelial cells may also express CD138. CD138 is a protein present on plasma cells in the bone marrow and on certain epithelial cells. Using this method plasma cells are selected from the population of CD38 cells by exclusion of all nonplasma cells with CD38 positivity using lineage specific markers such as CD3 CD14 CD16 CD19 and CD123. After CD138 immunohistochemistry staining the plasma cell membrane showed strong positive staining while the cytoplasm showed weak positive stainingUnder microscopic observation the nucleus was rounded but located on one side of the cell and the thick chromatin was radially arranged along the nuclear. The loss of CD138 expression from atypical cells is reported to be an early.
Source: pinterest.com
CD138 syndecan-1 a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. Epithelial cells and endothelial cells may also express CD138. A 69-year-old man with a history of CD138 plasma cell myeloma PCM who received chemotherapy regimens and stem cell transplant presented for bone marrow biopsy which revealed sheets of atypical plasma cells with abundant amphophilic cytoplasm occasional binucleation and distinct perinuclear hof panels A-B. CD138 syndecan-1 a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms.
Source: pinterest.com
CD138 also designated syndecan-1 is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The criteria for CD138 immunohistochemically stained specimens 9 12. In normal tonsil tissue CD138 strongly stains the membranes of mature plasma cells and squamous epithelial cells. CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma SCC of head and neck and larynx.
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CD138 Concentrate Clone MI15. CD138 expression is reduced during malignant transformation of various epithelia and CD138 is. In normal tonsil tissue CD138 strongly stains the membranes of mature plasma cells and squamous epithelial cells. In normal tonsil tissue CD138 strongly stains the membranes of mature plasma cells and squamous epithelial cells. If a patient is to be tested for cancer CD138 stains can be used to spot tumor cells.
Source: pinterest.com
CD138 is a protein present on plasma cells in the bone marrow and on certain epithelial cells. Original magnification 100 Wright-Giemsa stain A and 40. CD138 protein and mRNA levels were first assayed by flow cytometry analysis using an anti-CD138 DL-101 clone and qRT-PCR respectively in MM cell lines n. To improve minimal residual disease MRD detection a new CD138-independent strategy based on CD38 positivity of plasma cells was recently published by Muz et al. Epithelial cells and endothelial cells may also express CD138.
Source: pinterest.com
In normal tonsil tissue CD138 strongly stains the membranes of mature plasma cells and squamous epithelial cells. CD138 syndecan-1 is a transmembrane proteoglycan with a main cellular expression in stratified and simple epithelia. It is further found on a subset of plasma cells in peripheral blood and certain lymphoid tissues. CD138 expression is reduced during malignant transformation of various epithelia and CD138 is. After CD138 immunohistochemistry staining the plasma cell membrane showed strong positive staining while the cytoplasm showed weak positive stainingUnder microscopic observation the nucleus was rounded but located on one side of the cell and the thick chromatin was radially arranged along the nuclear.
Source: pinterest.com
Epithelial cells and endothelial cells may also express CD138. Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma SCC of head and neck and larynx. The CD138 antigen is neither expressed on naive B cells germinal center B cells memory B cells nor on T cells or monocytes. Levels also reduced in invasive SCC but not in SCC in situ Interpretation. CD138 Syndecan-1 is a heparan sulfate-rich integral membrane proteoglycan which functions as a matrix receptor for interstitial collagens fibronectin and thrombospondin.
Source: pinterest.com
This product should be interpreted by a qualified pathologist in conjunction with histological examination. CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. CD138 expression is reduced during malignant transformation of various epithelia and CD138 is. If a patient is to be tested for cancer CD138 stains can be used to spot tumor cells. CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms.
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